Last edited by Saramar
Thursday, July 30, 2020 | History

5 edition of Application of monoclonal antibodies in tumor pathology found in the catalog.

Application of monoclonal antibodies in tumor pathology

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  • 33 Currently reading

Published by Nijhoff, Distributors for the U.S. and Canada, Kluwer Academic Publishers in Dordrecht, Boston, Hingham, MA, USA .
Written in English

    Subjects:
  • Cancer -- Diagnosis -- Congresses,
  • Monoclonal antibodies -- Diagnostic use -- Congresses,
  • Tumor antigens -- Analysis -- Congresses,
  • Immunodiagnosis -- Congresses,
  • Immunohistochemistry -- Congresses,
  • Antibodies, Monoclonal -- congresses,
  • Antigen -- Antibody Reactions -- congresses,
  • Neoplasms -- immunology -- congresses

  • Edition Notes

    Statementedited by Dirk J. Ruiter, Gert Jan Fleuren & Sven O. Warnaar.
    SeriesDevelopments in oncology ;, 50
    ContributionsRuiter, Dirk J., Fleuren, Gert Jan., Warnaar, Sven O.
    Classifications
    LC ClassificationsRC270.3.M65 A67 1987
    The Physical Object
    Paginationxii, 391 p. :
    Number of Pages391
    ID Numbers
    Open LibraryOL2736610M
    ISBN 100898388538
    LC Control Number86031071

    Monoclonal antibodies are used to treat many diseases, including some types of cancer. To make a monoclonal antibody, researchers first have to identify the right antigen to attack. Finding the right antigens for cancer cells is not always easy, and so far mAbs have proven to be more useful against some cancers than others.   The most significant recent advances in the application of monoclonal antibodies (mAbs) to oncology have been the introduction and approval of .

    [CANCER RESEA , July ] Basic Principles and Applications of Monoclonal Antibodies in the Management of Carcinomas: The Richard and Hinda Rosenthal Foundation Award Lecture1 Jeffrey Schlom Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland The introduction of monoclonal antibodies revolutionized immunology. The development of human monoclonal antibodies was inspired primarily by the enormous clinical benefits promised by these reagents which can be used as anti-inflammatory reagents, anti-tumor reagents and reagents for passive immunization in a variety of pathologies.

    Monoclonal antibodies in the diagnosis, detection and therapy of cancer R. W. Baldwin Cancer Research Campaign Laboratories, University of Nottingham, Nottingham NG7 2RD Synopsis The production of monoclonal antibodies specifying tumour associated antigens is illustrated by studies with a spontaneously arising rat mammary carcinoma (Sp4).   After the successful introduction of monoclonal antibodies in general medicine, the migration to imaging and/or therapeutic applications may follow. It would be helpful if every biological product could find application in radiolabeled diagnostics or therapeutics. However, many antibody-related products that find use in general medicine are either.


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Application of monoclonal antibodies in tumor pathology Download PDF EPUB FB2

The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues.

During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. About this book The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues.

During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells.

Monoclonal antibodies can be used to identify and biochemically characterize tumor-associated antigens. Monoclonal antibody (MoAb) D9 was produced by immunization of BALB/c mice with a transformed cell line (D9) induced by transfection of NIH 3T3 cells with a c-H-ras oncogene in DNA isolated from a human lung carcinoma.

The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues.

Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease.

Application of monoclonal antibodies as cancer therapy in solid tumors Monoclonal antibodies have become an important new class of therapeutic agents approved for use in solid tumors. The Book of Longings. Sue Monk Kidd. € €. This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in and is now provided online in association with Cancer Immunology Research.

Monoclonal antibody-based treatment of cancer has been established as one of the most successful therapeutic strategies for both hematologic malignancies and solid tumors in the last 20 years. Monoclonal antibodies have a wide range of therapeutic applications.

MAbs are used in the treatment of cancer, transplantation of bone marrow and organs, autoimmune diseases, cardiovascular diseases and infectious diseases. The therapeutic applications of MAbs are broadly grouped into 2 types: (A) Direct use of MAbs as therapeutic agents.

For example, some monoclonal antibodies mark cancer cells so that the immune system will better recognize and destroy them. An example is rituximab, which binds to a protein called CD20 on B cells and some types of cancer cells, causing the immune system to kill them.

B cells are a type of white blood cell. Other monoclonal antibodies bring T cells close to cancer cells, helping the immune cells kill the cancer cells. Immunohistochemistry (IHC) is an important application of monoclonal as well as polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease.

IHC is widely used for diagnosis of cancers; specific tumor antigens are. Monoclonal antibodies have become the preferred reagents in many research and diagnostic applications and are increasingly used in therapy of cancer and immunological disorders, generating a.

Monoclonal antibody (mAb)-based products are highly specific for a particular antigen. This characteristic feature of the molecules makes them an ideal tool for many applications including cancer diagnosis and therapy.

Several reviews have recently appeared on the use of monoclonal antibodies (MAbs) in breast cancer research and diagnosis (1, 2, 3, 4, 5). In particular the chapter written by Sloane (4) places immunohistochemistry of breast and breast tumors in the context of pathology and also underlines the continuing value of more conventional staining techniques.

Engineering Monoclonal Antibodies: Production and Applications December In book: Omics Technologies and Bio-engineering Volume 1:Towards Improving Quality of Life (pp). Monoclonal antibodies used in oncology exert direct anti-tumor effect thanks to mechanisms ranging from induction of apoptosis to recruitment of effector cells from innate immunity.

However, they can also induce long-lasting anti-tumor protection through the induction of adaptive immunity where CD4+ and CD8+ T cells play a central role. Monoclonal antibodies are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance or mimic the immune system's attack on cancer cells.

They are designed to bind to antigens that are generally more numerous on the surface of cancer cells than healthy cells. How do monoclonal antibody drugs work. Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy.

Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action. In addition, antibodies can directly target tumor cells while simultaneously promoting the induction of long-lasting anti-tumor immune responses.

JH Baars, JLM de Ruijter, F SmedtsThe applicability of a keratin 7 monoclonal antibody in routinely Papanicolaou-stained specimens for the differential diagnosis of carcinomas Am J Clin Pathol, (), pp.

In view of the explosion of the present clinical use of monoclonal antibodies (mAbs), not only in the treatment of cancer, but also of autoimmune diseases, I was asked to review the development of mAbs in tumor diagnosis and therapy, with some illustrations of our own contribution in the field.

The initial use of radiolabeled mAbs for tumor targeting and radioimmunotherapy led to the extensive clinical.

An early hope for monoclonal antibodies (mAbs) was that they would serve as tumor-specific magic bullets in two ways. As bullets, they would move through the blood to reach and attack tumor targets.

The exquisite specificity of a single antibody would provide the magic. Experience with tumors outside the brain has begun to justify this hope. For example, monoclonal antibodies that react with cancer antigens can be used to identify cancer cells in tissue samples.

Moreover, if short-lived radioactive atoms are added to these antibodies and they are then administered in tiny quantities to a patient, they become attached exclusively to the cancer tissue.Monoclonal antibodies are biological drugs used to treat cancers, certain types of arthritis, lupus, MS, and IBD.

Side effects are itching, rash, chills, cough and constipation, and may include hepatitis, cancer and congestive heart failure. Monoclonal antibodies are routinely used in several fields but the great challenge has been their use as therapeutic agents for the treatment of diseases, such as breast cancer, leukemia, asthma, macular degeneration, arthritis, Crohn’s disease, and transplants, among others.